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Increased Incidence of T-Cell Malignancies in Patients with Chronic Lymphocytic Leukemia

Journal: Annals of Hematology & Oncology (Vol.2, No. 2)

Publication Date:

Authors : ; ; ; ; ; ;

Page : 1-3

Keywords : Chronic lymphocytic leukemia; T-cell lymphoma; Neoplastic cell transformation; Cohort studies;

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We present a patient with chemotherapy-refractory Chronic Lymphocytic Leukemia (CLL) in whom postmortem examination showed hepatosplenomegaly, with both multiple small-cellular CLL lesions and large-cellular, monoclonal T-cell infiltrates. Following this case, the co-incidence of T-cell malignancies and CLL was studied using Dutch and American cancer registry databases. Analysis showed an excess risk for T-cell malignancies in CLL patients, with increased standardized incidence ratios compared with the general population and all cancer survivors in the databases. We hypothesize that CLL cells interact with T-cells in the microenvironment, facilitating malignant transformation.

Last modified: 2016-08-02 20:20:47