Extended Release Topiramate Formulations in Epilepsy

Topiramate is a novel antiepileptic medication with multiple mechanisms of actions. It is a broad spectrum antiepileptic drug and it is indicated for adjunctive treatment, conversion to monotherapy and initial monotherapy of partial onset and primary generalized epilepsies, the Lennox-Gastaut syndrome as well as for treatment of migraine headaches. It is also used clinically for a variety of neurologic and psychiatric disorders as well as for obesity. Recently, two extended release formulations of topiramate were approved by the FDA for treatment of epilepsy. We review these two formulations in this paper.