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Phosphodiesterase as a Drug Target of Alzheimer’s Disease

Journal: Austin Alzheimer's and Parkinson's Disease (Vol.2, No. 1)

Publication Date:

Authors : ;

Page : 1-4

Keywords : Amyloid; Alzheimer’s disease; Phosphodiesterase; Phosphodiesterase inhibitor; ; cAMP; cGMP; Signal transduction; Therapy; Drug;

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Although amyloid hypothesis is widely accepted, recent findings indicate that the hypothesis may be incorrect, suggesting that Aβ is not a suitable drug target in Alzheimer’s disease. Accumulating evidences and new findings suggest that phosphodiesterases is involved in Alzheimer’s disease. In this review, I introduce the current state of phosphodiesterases and their inhibitors as for Alzheimer’s research.

Last modified: 2016-08-11 19:27:21