IMMUNOHISTOCHEMICAL CHARACTERISTICS OF INTRATHYROIDAL LYMPHOCYTES PHENOTYPE IN AUTOIMMUNE THYROIDITIS

The purpose of the research was to study the local immune processes in thyroid tissue in patients with autoimmune thyroiditis by immunohistochemistry of intrathyroidal lymphocytes phenotype. A highly reliable direct correlation between the number of cell phenotypes CD1α +, CD3 +, CD4 +, CD8 +, CD23 +, CD25 + , which infiltrate the nodules in the thyroid gland in patients with autoimmune thyroiditis, and the number of the same cells which infiltrate the tissue surrounding the nodules was identified. It has been noted, that the number of B-lymphocytes and CD8 + T cells is significantly higher in the lymphoid infiltrates as compared to nodules, and the correlation CD1a / CD3 and CD25 / CD3 in stroma of nodules is significantly higher than in the lymphoid infiltrate.