NEW ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CHLORPHENIRAMINE MALEATE BY USING UV-VISIBLE SPECTROPHOTOMETRY

A simple UV-Visible Spectrophotometric method was developed for the determination of chlorpheniramine maleate in pure and its pharmaceutical formulations. chlorpheniramine maleate exhibited maximum absorption at 262nm in 0.1N HCl and obeyed linearity in the concentration range of 10-60 μg/ml. The proposed method was statistically validated.All the proposed methods are simple, selective, reproducible, sensitive and accurate with good precision. Some of the methods were proved to be superior to most of the reported methods. All these proposed methods for estimation of selected drugs such as chlorpheniramine maleate were successfully applied either in bulk or pharmaceutical formulations. The proposed methods can be used as alternative methods to the reported ones for the routine determination of selected drugs under the study in bulk and pharmaceutical dosage forms. Keywords: chlorpheniramine maleate, UV-Visible Spectrophotometer, Hydrochloric acid.