Collapsing Glomerulopathy in Renal Transplant Recipients - Two Case Reports

Collapsing focal segmental glomerulosclerosis or Collapsing glomerulopathy (CG) is a distinct clinicopathological variant of focal segmental glomerulosclerosis characterized pathologically by the segmental or global collapse of the glomerular capillaries, marked hypertrophy and hyperplasia of visceral epithelial cells , and severe tubulointerstitial disease and clinically characterised by nephrotic proteinuria and rapidly progressive renal failure. This has been reported in transplanted kidneys either as recurrent or de novo disease, resulting in allograft failure. We report two renal transplant recipients who developed graft dysfunction, nephrotic proteinuria and biopsy proven CG. Work-up for secondary causes was negative and renal function declined rapidly with the need for dialysis in both the patients.