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Propofol induced severe neuroexcitatory symptoms during emergency laparotomy

Journal: International Journal of Basic & Clinical Pharmacology (Vol.2, No. 5)

Publication Date:

Authors : ;

Page : 645-646

Keywords : Propofol; Seizures; Neuroexcitatory symptoms;

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Propofol is a widely used intravenous agent for general anesthesia and sedation. Propofol is associated with a variety of neuroexcitatory events including: opisthotonus, muscle rigidity, myoclonus, and seizures collectively termed as seizure-like phenomenon (SLP). We report a rare case of propofol induced severe neuroexcitatory symptoms at the time of induction in a young male presenting for emergency laparotomy. He developed generalized tonic- clonic seizures which resulted in dislodgement of intravenous cannula. Immediately a new intravenous cannula was inserted with difficulty during convulsions and injection thiopentone 200 mg bolus was given. Convulsions subsided within a minute. Patient remained hemodynamically stable and surgery was uneventful. He developed emergence agitation which was treated with injection midazolam. Patient recovered with no neurologic sequelae. [Int J Basic Clin Pharmacol 2013; 2(5.000): 645-646]

Last modified: 2013-10-17 11:00:54