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Expanding horizons of anticoagulant therapy: Dabigatran etexilate a novel oral anticoagulant

Journal: International Journal of Basic & Clinical Pharmacology (Vol.2, No. 5)

Publication Date:

Authors : ;

Page : 663-667

Keywords : Dabigatran etexilate; Direct thrombin inhibitor; Novel anticoagulant; Stroke prevention; Atrial fibrillation; Venous thromboembolism; Orthopaedic surgery;

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Thrombo-embolic disease is a major challenging clinical problem associated with significant mortality and morbidity. Anticoagulation with the existing heparin products and vitamin K antagonist (VKA) anticoagulants are still the mainstay of management. However, due to the risk of bleeding and well-documented drawbacks, the quest for a novel oral anticoagulant has led to the clinical development of dabigatran etexilate. Dabigatran etexilate is a direct thrombin (IIa) inhibitor which has recently been approved in India for prevention of venous thromboembolic events (VTE) in patients who have undergone major orthopaedic (total knee or hip replacement) surgery and for prevention of stroke, systemic embolism and reduction of vascular mortality in adult patients with atrial fibrillation. Thus dabigatran etexilate is a promising alternative to the current heparin products and VKAs in patients who require long-term oral anticoagulation. [Int J Basic Clin Pharmacol 2013; 2(5.000): 663-667]

Last modified: 2013-10-17 11:06:35