FORMULATION AND EVALUATION OF ELEMENTARY OSMOTIC PUMP DOXOFYLLINEJournal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.03, No. 08)
Publication Date: 2016-08-17
Authors : M. Naga Ganesh; Y. Madhusudan Rao;
Page : 916-925
Keywords : Elementary osmotic pumps; Doxofylline; plasticizer.;
In the present study elementary osmotic pumps (EOP) of Doxofylline were formulated and evaluated. The target release profile was selected and different variables were optimized to achieve the same. Formulation variables like nature and concentration of plasticizer (0-20% w/w of polymer) osmogens comparission and role of osmogen concentration, aperture diameter and coat thickness were found to affect the drug release from the developed formulations. Doxofylline release was directly proportional to the level of plasticizer and osmotic pressure generated by an osmotic agent. Drug release from developed formulations was independent of pH and agitation intensities of release media. Burst strength of the exhausted shells increased with increase in coat thickness but decreased with increase in level of hydrophilic plasticizer. Keywords: Elementary osmotic pumps, Doxofylline, plasticizer.
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