FLOATING MICROSPHERES FOR GASTROINTESTINAL DISORDERS

Drug absorption in the gastrointestinal tract is a highly variable process. Floating microspheres are promises to be a potential approach for gastric retention enhances the bioavailability and controlled delivery of various therapeutic agents. Significant attempts have been made worldwide to explore these systems according to patient requirements, both in terms of therapeutic efficacy and compliance. Floating microspheres as gastro retentive dosage forms precisely control the release rate of target drug to a specific site and facilitate an enormous impact on health care. These systems also provide tremendous opportunities in the designing of new controlled and delayed release oral formulations, thus extending the frontier of futuristic pharmaceutical development. Furthermore, recent innovations in pharmaceutical investigation will surely provide real prospects for establishment of novel and effective means in the development of these promising drug delivery systems. Keywords: Gastro Retention, Hollow microspheres, Floating microspheres, Short halflife, Solvent Diffusion, Floating drug delivery system (FDDS).