Micro-Particles and Their Role in Various Clinical Settings

A microparticles (MPs) submicron membrane vesicle, expresses a panel of oxidized phospholipids and proteins that plays a vital role in the normal haemostatic response to vascular injury. An important role in clinical diseases is also observed. In nearly all thrombotic diseases increased platelet-derived MP, endothelial cell-derived MP and monocyte-derived MP concentrations are reported. However, a clear importance of MPs in varied clinical conditions still remains disputed. Many studies have reported that the MPs cellular origin and composition are based on the type of disease, the disease state and medical treatment. Additionally, many different functions have also been attributed to MPs. Thus, the number and variety of clinical disorders related with elevated MPs is currently swelling.