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Molecular Physiology of G-CIMP+ Glioblastomas: Therapeutic Implications

Journal: Journal of Gene therapy (Vol.2, No. 1)

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Authors : ; ; ; ; ;

Page : 01-02

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A fundamental premise of gene therapy as it pertains to oncology is precision medicine, whereby therapeutic intervention is matched to unique vulnerabilities dictated molecular physiology of the cancer [1]. Cancers previously thought to be single clinical entities are now stratified based on these molecular physiologies [2]. As an example, glioblastoma, the most common form of primary adult brain cancer [3], is now recognized as an umbrella term that encapsulates a spectrum of subtypes that are defined by shared molecular physiologies [4]. A notable glioblastoma subtype involves the Glioma CpG IslandMethylator (G-CIMP) phenotype.

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Last modified: 2016-12-12 15:27:40