ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF STAPHYLOCOCCUS AUREUS ISOLATED FROM VARIOUS CLINICAL SAMPLES IN A TERTIARY CARE HOSPITAL

Background: Staphylococcusaureusisanosocomialpathogen,causinghighmorbidityandmortality.TheprevalenceofMRSAinfectionandthesusceptibilitypatternofStaphylococcusaureusvarieswiththeregion. WiththisbackgroundpresentstudywasundertakentodeterminetheprevalenceofstaphylococcusaureusandMethicillin-ResistantStaphylococcusaureus(MRSA)isolatesfromvariousclinicalsamplesandtheirantimicrobialsusceptibilitypatterninatertiarycarehospital. MaterialsandMethods: Inthisretrospectivestudy,atotalof240isolatesofStaphylococcusaureuswascollectedfromaclinicalspecimen,betweenJune2021toMay2022intheDepartmentofMicrobiology,MGMMedicalCollegeandHospital,Aurangabad.StaphylococcusaureuswasidentifiedandtheirantibioticsusceptibilitytestingwasdeterminedbyusingVitek2compactsystemanddatawereanalyzed. Result: Inourstudytotalof240StaphylococcusaureuswereisolatedandtheprevalenceofMSSAwas27.5%andtheprevalenceofMRSAwas72.5%fromvariousclinicalsamples. Outof240Staphylococcusaureusisolates,116(48.33%)wereresistanttoBenzylpenicillin,followedbyCiprofloxacin212(88.33%),Levofloxacin212(88.33%),Erythromycin154(64.17%),Clindamycin122(50.83%),Trimethoprim/Sulfamethoxazole120(50.00%),Gentamicin56(23.33%),Rifampicin15(6.25%)andTigecycline6(2.50%). Conclusion: AhighprevalenceofMRSA(72.50%)wasobservedinourregion.ThemosteffectiveantibioticsforthetreatmentofMRSAwereLinezolid,Vancomycin,Teicoplanin,andTetracycline.TheseantibioticsshouldbekeptreservedforthetreatmentofMRSAinfection. Regularsurveillanceofhospital-associatedinfectionsisrequiredforassessingthetrendsintheantibioticresistanceofpathogensforstrengtheningthecontrolmeasurestopreventthespreadandreducetheemergenceofmultidrug-resistantMRSAinfections.