A COMPARATIVE STUDY BETWEEN MAGNESIUM SULPHATE AND DEXMEDETOMIDINE FOR ATTENUATION OF HAEMODYNAMIC PRESSOR RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

Backround:Direct laryngoscopy followed by endotracheal intubation is prone to haemodynamic fluctuations which may be detrimental in subjects with coronary artery disease, hypertension, and cerebral vascular disease. The aim is we wanted to compare Dexmedetomidine with Magnesium sulphate to determine the better drug with regard to attenuation of the haemodynamic responses during laryngoscopy and endotracheal intubation Objectives: 1. To study the effects of magnesium sulphate and dexmedetomidine in attenuation of haemodynamic response to laryngoscopy and intubation . 2. To study the side effects of the above drugs Methodology: This study was conducted among 60 subjects aged between 20 and 60 years belonging to ASA grade IandII, posted for elective surgeries under general anaesthesia. The study subjects were included randomly in 2 groups of 30 each. Group A received intravenous Dexmedetomidine 0.75µg/kg body weight and Group B received intravenous Magnesium sulphate 50%, 25 mg/kg body weight, both diluted in 20 ml of normal saline. Both were administered intravenously over 10 minutes. Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Pressure (MAP), Heart Rate (HR) were noted at baseline, after study drug infusion, before induction, before intubation,1,2,3,4,6,8,10 and 15th min after intubation. If any sideeffects present, were also noted and treated. Result: Data was compared using paired t-test,chi-square test,Fisher exact probability test and the reduction in the heart rate was found to be statistically significant (p<0.05) at all intervals. There was also significant decrease in systolic,diastolic and MAP during the immediate post intubation period. Conclusion:Dexmedetomidine 0.75 μg/kg IV infusion is more effective than Magnesium sulphate 25mg/kg IV infusion for attenuating the haemodynamic response to laryngoscopy and intubation in elective general surgical patients.