Spontaneous Regression of Atypical Primary Cutaneous Diffuse Large B-Cell Lymphoma on Cheek upon Methotrexate Withdrawal

Primary cutaneous diffuse large B?cell lymphoma (PCDLBCL) accounts for approximately 6% of all cutaneous lymphomas. PCDLBCL are usually seen in leg, however they can be seen in other location in 15% of cases.It usually affects elderly women and is associated with poor prognosis.Solitary lesions are relatively rare. The recommended treatment is as for systemic diffuse large B?cell lymphoma (DLBCL). We present an atypical case of PCDLBCL occurring on the cheek of an elderly woman and its spontaneous resolution upon withdrawal of methotrexate therapy for rheumatoid arthritis. It is paramount to recognise these cases and correlation being undertaken in order to avoid inappropriate chemotherapy.