Childhood Granulomatous Perioral Dermatitis with Good Responses to Minocycline and Topical Tacrolimus, Extraordinary Significance

Childhood Granulomatous Perioral Dermatitis (CGPD) is a rare disease characterized as an eruption, which is seen predominantly in children and represents a granulomatous form of perioral dermatitis or of acne agminata. It is a condition of unknown etiology affects prepubescent children of both sexes and typically persists in several months, characterized by asymptomatic papular eruptions generally confined to the central area of the face with clustering around the mouth, eyes and ears. The histopathology shows a granulomatous pattern. We report a 24-year-old Chinese girl with multiple, discrete, red to brown papules on erythematous base of 2-months duration on the perioral and periocular areas. Histopathological examination demonstrated dermal granulomatous infiltrates. The patient show good response to the combination treatment of oral Minocycline and topical Tacrolimus. CGPD is the disease of children, but in this rare case the disease occur in adult, with good response to oral Minocycline and topical Tacrolimus.