Another Example of a Successful Use of Computational and Modeling Tools from the Theory of Dynamic Systems in Pharmacokinetic Modeling

The objective of the current more or less theoretical study was to provide another example of a successful use of computational and modeling tools from the theory of dynamic systems in pharmacokinetic modeling. The tools considered here, were used to develop mathematical models of the pharmacokinetic behavior of ethanol following its intravenous infusion to dogs. The data used in this study, were drawn from the study: (Rheingold JL, Lindstrom RE, Wilkinson PK, A new blood-flow pharmacokinetic model for ethanol. J Pharmacokinet Biopharm. 1981; 9:3261-3278). The method developed by Dedík and Ďurišová was employed for modeling purposes. A description of the method considered here has been published in the study: Dedík L, Ďurišová M. (Advanced system approach based method for modeling biomedical systems. In International Conference of Computational Methods in Sciences and Engineering, ICCSE 2004. T. Simos, G. Maroulis (Eds). Koninklijke Brill NV: Leiden, Netherlands 2004, 136-139). As it follows from the results obtained, the mathematical models developed successfully described the pharmacokinetic behaviorof infused ethanol in all dogs studied. The modeling method used inthe current more or less theoretical study is an alternative modeling method to modeling methods frequently used in pharmacokinetics.