COMPARISON OF PRECURARISATION WITH ROCURONIUM BROMIDE AND VECURONIUM BROMIDE FOR SUCCINYLCHOLINE HYDROCHLORIDE INDUCED POST OPERATIVE MYALGIA

BACKGROUND: The study was to compare the effectiveness of the pre-treatment with rocuronium bromide and vecuronium bromide for prevention of succinylcholine hydrochloride induced fasciculation and post operative myalgia, to evaluate intubating conditions and to assess any changes in serum potassium and serum creatinine phosphokinase level. MATERIAL AND METHODS: 120 patients were divided into 3 groups according to precurarisation in the form of either 0.06 mg/kg of Inj. rocuronium bromide or 0.01mg/kg of vecuronium bromide or 2 ml of normal saline intravenously. Induction was done with inj. thiopentone sodium 5mg/kg and inj. succinylcholine hydrochloride 1.5 mg/kg intravenously. Severity of muscle fasciculation was assessed by four point scale. After 60 seconds, laryngoscopy and intubation was done. The intubating condition was graded as excellent, good or poor. Blood sample was taken after 2 minutes of induction for serum K+ estimation and after 24 hours for serum creatinine phosphokinase estimation. Postoperatively on 1st, 2nd and 3rd day severity of myalgia was assessed and graded by using 4 point scale. Statistical analysis was done by using ANOVA, unpaired student’s t test and chi square test. RESULTS : Fasciculation was seen in 92.5% of saline group as compared to 22% and 32.5% in rocuronium bromide and vecuronium bromide group respectively. Myalgia was less with rocuronium bromide than with vecuronium bromide and saline group. Rise in serum potassium and creatinine phosphokinase was observed in saline group. CONCLUSION: The incidence and severity of fasciculations and post operative myalgia is greatly reduced by pretreatment with rocuronium bromide 0.06 mg/kg.