THE EFFECT OF EARLY POSTNATAL OVERNUTRITION ON PROOXIDANT-ANTIOXIDANT BALANCE AND NO-SYNTHASE ACTIVITY IN OLD RATS TISSUES

The peculiarities of changes of prooxidant-antioxidant balance, thyroid status and NO-synthase activity in tissues of 20-month-old rats after overnutrition during first month after birth were investigated. It was found out that body weight, thyroxine concentration, lipid hydroperoxides content and NO-synthase activity in ex-perimental rats were higher than in control ones. At the same time Se-dependent glutathione peroxidase ac-tivity was significantly decreased in liver of experimental rats. It is assumed that prooxidant-antioxidant sys-tem and thyroid state may be ones of the key links of the mechanism determining rats surviving in conditions of overnutrition.