INFLUENCE OF В-LYMPHOCYTES ON BONE MARROW RECOVERY OF THE IRRADIATED RECIPIENTS OF ALLOGENIC MIELOTRANSPLANT
Journal: The Journal of V.N. Karazin Kharkiv National University, series "Medicine" (Vol.15, No. 15)Publication Date: 2008-06-30
Authors : N.N. Popov; E.A. Romanova;
Page : 15-20
Keywords : transplantation; lymphocytes; bone marrow;
Abstract
The study of influencing of enriching allogenic mielotransplant by B-lymphocytes on recovery of hemopoiesis and immunogenesis of the irradiated recipients and possibility of development at them GVHD was the purpose of work. It is rotined that application of В-lymphocytes is joint with mielocariocytes renders a stimulant effect on renewal total organcellularity, number of CFU, lymphocytes of bone marrow of the lethally irradiated recipients. Adding of В-lymphocytes to allogenic T-depleted mielotransplant is instrumental in forming of tolerance to the donor cells and establishment of cellular chimerism.
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