PROTEOMICS AS A TOOL TO DECIPHER NOVEL MECHANISTIC CANDIDATES IN CARDIAC PATHOPHYSIOLOGY

Cardiac diseases resulting in heart failure have become one of the major causes of mortality as well as reduced quality of life for people all over the world. In an effort to understand the mechanisms underlying cardiac diseases and devise preventive as well as therapeutic measures, a lot of research has been carried out over the years. Two systems biology approaches- proteomics and computational modelling have drastically changed the field of cardiac research by delivering vast amounts of relevant molecular data thus enhancing the interpretation of both clinical as well as subcellular events dictating pathophysiology during compromised heart function. This review specifically focuses on the contributions of such systems biology approaches in proper understanding of the pathophysiology of diseased myocardium.