LET-7A AS A TUMOR SUPPRESSOR MODULATES INVASION VIA SMAD2 SIGNAL IN BREAST CANCER
Journal: International Journal of Cancer and Oncology (Vol.2, No. 2)Publication Date: 2015-06-02
Authors : Wentong Li;
Page : 1-4
Keywords : Let-7a; Tumor Suppressor; Smad2; Breast Cancer;
Abstract
TGF-β elicits tumor promoting effects through its ability to induce EMT which enhances invasiveness and metastasis, the perturbations of TGF-β/Smad signaling are central to carcinogenesis in most of organs. A shift in Smad2/3 phosphorylation from the carboxy terminus to linker sites is a key event determining biological function of TGF-β. Here, we showed that let-7 was associated with breast cancer development and progression by directly targeted Smad2, suggesting a tumor suppressor role of let-7 and its target Smad2 is critical regulators of TGF-β signaling in breast cancer.
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