ANTHRACYCLINE-INDUCED CHANGES OF INTRACARDIAC HEMODYNAMICS

The article contains review of world literature and own observations concerning anthracycline cardiotoxicity. Changes in basic indices of systolic and diastolic cardiac functions induced by different cumulativedozes of anthracyclines are evaluated by modern methods of research. The question about safe dosage of anthracycline antibiotics is discussed. The comparative character of different representatives of this group ofmedicines according to their toxicity levels is described. The main purpose of the study is to find the mostsensitive criterion of myocardial damage after anthracycline therapy which can be revealed on the very early stages.