ISCHEMIA EFFECT ON ATPASE ACTIVITY OF HEART MITOCHONDRIA IN YOUNG AND OLD RATS
Journal: The Journal of V.N. Karazin Kharkiv National University, series "Medicine" (Vol.1, No. 1)Publication Date: 2000-12-30
Authors : V.N. Dzuba; Yu.V. Nikitchenko; T.A. Shmonina;
Page : 25-29
Keywords : ISCHEMIA EFFECT ON ATPASE ACTIVITY OF HEART MITOCHONDRIA IN YOUNG AND OLD RATS;
Abstract
ATPase activity alterations in rats of different age groups during the total myocardial ischemia were studied. It was determined that only mitochondrial oligomycin-sensitive ATPase was sensitive to effect of the total myocardial ischemia. The fact that addition of magnesium ions in the incubation medium eliminated ischemic effect in 3-months old rats and weakened it in 24-months old rats pointed to important role of magnesium ions in structure-functional reconstruction of mitochondria under myocardial ischemia. Young 3months old rats were established to be more tolerant to myocardial ischemic damage thanold animals.
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