EVALUATION OF TOLENORM OIL AND TOLENORM OINTMENT IN ‘NEAR SKIN’ MODEL FOR THE TREATMENT OF VITILIGO

Combination of Tolenorm oil and Tolenorm ointment was tested on co - culture of melanocytes and keratinocytes in vitro to understand whether the effect of these Siddha drugs results in the transfer of melanin from melanocytes to keratinocytes. The findings of the present study authenticates the established likely mechanism of action of these Siddha drugs with reference to up - regulation of tyrosinase activity , melanogenesis, dendrite formation and increase in dendrite length directly impact the pigment transfer.