HYPERTENSION AND ENDOTHELIAL DYSFUNCTION IN COMORBID PATHOLOGY: DIABETES MELLITUS AND PRIMARY HYPOTHYRIODISM

The article presents the results of studying the characteristics of arterial hypertension and endothelial dysfunction in patients with diabetes mellitus type 1 and diabetes mellitustype 2 in combination with primary hypothyroidism. We revealed the increased time index of diastolic blood pressure and disorders circadian blood pressure profile with high prevalence of non-dippersrate. Decrease of endothelium-dependent vasodilation and increased concentration of endothelin-1 were diagnosed. The analysis showed the correlation of endothelial function parameters with carbohydrate and lipid metabolism, blood pressure, insulin resistance, TSH level in patients with combined pathology.