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IMMUNE THROMBOCYTOPENIA AFTER ALLOGENEIC STEM CELL TRANSPLANTATION: CASE REPORT AND BRIEF OVERVIEW OF TREATMENT STRATEGIES

Journal: Journal of Hematology and Oncology Research (Vol.2, No. 3)

Publication Date:

Authors : ; ; ; ; ;

Page : 3-8

Keywords : LLeukemia; Allogeneic stem cell transplantation; Immune thrombocytopenia; Eltrombopag;

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Abstract

Immune thrombocytopenia (ITP) is a rare but well-recognized post-allogeneic hematopoietic stem cell transplant (HSCT) autoimmune complication for which a standard treatment approach is lacking. Herein we report on an adult patient affected by high-risk acute myeloid leukemia (AML) who developed a post-HSCT ITP. Due to the refractoriness to first-line therapies the patient underwent the thrombopoietin (TPO) mimetic Eltrombopag obtaining the ITP resolution. We also discuss the clinical course of ITP in post-HSCT setting and pros and cons of different therapeutic strategies, focusing on the emerging role of TPO mimetics.

Last modified: 2017-02-03 04:04:25