The link between subclinical thyroid dysfunction and metabolic syndrome

Aim of study ? to determine the link between sex and age of patients, body weight, indexes of carbohydrate homoeostasis and functional state of the thyroid gland in patients with ischemic heart disease. Materials and methods. 248 patients with coronary heart disease were included in the study. We calculated body mass index (BMI) according to the formula: weight (kg)/height (m2). Level of insulin and TSH were measured by IFA method( 3rd generation). Index HOMA-IR was calculated with the formula: Insulin (IU/ l)×Glucose (mmol/l)/22,5. Results and discussion. Subclinical hypothyroidism was revealed in 16.7% of women and 6.9% of men. Elevated TSH levels correlated with increased BMI in both the groups. In patients with obesity and DM type 2 TSH level was significantly higher, than in patients without obesity. Index HOMA-IR was also high in patients with truncal obesity. Conclusions. Mild thyroid dysfunction to some extent can potentiate development of metabolic syndrome in predisposed patients.