Analysis Of Behavioral Satiety Sequence Of Fluoxetine In Wistar Albino Rats

Background -Fluoxetine ( SSRI or selective serotonin reuptake inhibitor ) is a drug that is currently used as an antidepressant and is being experimented as an anorectic. The mechanism of its anorectic action is poorly understood.Aim -The aim of the study is to determine whether Fluoxetine is a primary or a secondary anorectic reliably by analyzing the behavioral satiety sequence (BSS).Materials and methods - Wistar male albino rats were randomly divided into 2 groups with 6 animals in each group. Fluoxetine 8 mg per kg was administered orally to the test group and vehicle (sterile water) to the control group for 14 days. Analysis of behavioral satiety sequence (BSS ) was done after 14 days comparing both the groups. Then the animals were allowed a wash out period of 45 days after which the two groups were crossed over and the same parameters were studied.Results-The control group exhibited normal behavioral satiety sequence (BSS ) whereas Fluoxetine treated animals showed acceleration of the behavioral satiety sequence.Conclusion-A primary anorectic acts by acceleration of the behavioral satiety sequence (BSS) whereas a secondary anorectic acts by disruption of the sequence. From this study we can conclude that Fluoxetine is a primary anorectic drug.