Computational genomic study of LTP pathway in the context of Raf/Ksr homologue in human and chimpanzee
Journal: International Journal of Biosciences (IJB) (Vol.1, No. 4)Publication Date: 2011-08-09
Authors : Farzana Ahmed; Abdullah-Al-Emran;
Page : 36-50
Keywords : Comparative genomic study; long term potentiation; Raf/KSR1.;
- Computational genomic study of LTP pathway in the context of Raf/Ksr homologue in human and chimpanzee
- Non-Genomic Pathway Corticosteroid in HIV Patient with Pneumocystis Pneumonia - A Case Report
- Gene Expression and Pathway Detection for Diabetic Nephropathy using Computational Intelligence in Bioinformatics
- Genomic DNA Isolation from Fungi, Algae, Plant, Bacteria and Human Blood using CTAB
- Methodological function of the “genomic information” notion for human genome interdisciplinary researches
Abstract
LTP (Long Term Potentiation) pathway, which is responsible for long-term memory development is defined as the long-lasting enhancement in communication between two neurons that results from stimulating them simultaneously. One of the most important genes concerning this LTP pathway is Raf which actually encodes for KSR1 (kinase suppressor of ras-1) compartmentalizes Hippocampal Signal Transduction and sub serves synaptic plasticity and Memory formation has been explored through the use of comparative genomics in this work. For this purpose, syntenic regions for KSR1 genes in human, chimpanzee, mouse and other organisms are computationally searched to find about the conserved regions and their function through the course of evolution. A coding region was found on chromosome 16 syntenic region for KSR1 of chimpanzee. Sequence comparisons among members of the Raf family reveal the presence of three blocks of conserved sequences: conserved regions (CR) 1, 2, and 3. In this work conserved regions are found in near the C-terminal and N-terminal region was absent in both human and chimpanzee which suggests C terminal region is very important and N ?terminal region is dispensable for raf-1 activity which supports the previous finding. Phylogenetic analysis showed that the KSR1 of human and chimpanzee are evolutionary distant from other organisms and human is most closely related with chimpanzee than any other organism which is also supported by previous evolutionary concept.
Other Latest Articles
- NaCl stress-induced growth, water and ions contents changes on in vitro selection of salt tolerant and salt sensitive callus of wheat (Triticum durum Desf.)
- Germination performance of some legume crops under varying filter paper mostures
- Antimicrobial interaction of Lactococcus lactis subsp. lactis against some pathogenic bacteria
- Common vetch Vicia sativa L. response to gibberellic acid application (GA3), supplementary irrigation and its water stress critical stages
- Investigation of molecular biology of leukaemia inhibitory factor (LIF): A Bioinformatics approach
Last modified: 2017-02-28 02:10:53