CHANGE OF PROOXIDANT ACTIVITY IN CHRONIC RENOCARDIAC SYNDROME AND ANTYHYPERTENSIVE THERAPY

We determined changes in activity of the prooxidant systems and indicators of inflammation in patients with chronic renocardiac syndrome. Thus, namely 33 patients with arterial hypertension and chronic kidney disease were examined for changes during chronic glomerulonephritis, as well as under the influence of antihypertensive therapy (fosinopril, diltiazem). Comparative evaluation of key indicators (pro-and antioxidant system) was associated with decrease of the prooxidant systems activity and reduction of its activity due to treating with antihypertensive drugs, which reduced the activity of rennin-angiotensin-aldosterone system.