CYTOKINES IN THE PATIENTS WITH CHRONIC RENOCARDIAC SYNDROME REGARDING TO THE RENAL FUNCTIONJournal: Journal of Clinical and Experimental Medical Research(JC&EMR) (Vol.1, No. 2)
Publication Date: 2013-07-02
Authors : Demikhova N. V.;
Page : 196-200
Keywords : cytokines; renocardiac syndrome; chronic renal failure.;
115 patients with chronic renocardiac syndrome were examined. They had an excessive increase of pro-inflammatory (IL-1β) and anti-inflammatory (IL-10) cytokines in the serum. In the patients with preserved renal function were revealed the predominance of IL-10. During development of chronic renal failure (CRF), there was the preferential increase of IL-1β. Chronic renal failure was characterized by a change in focus of immunity during the disease progression. In the early stages of chronic glomerulonephritis dominated humoral immunity. Further progression of the disease with predominance of IL-1β on IL-10 indicated the activation of the cellular immune response.
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