Collagen-Albumin-Gentamicin Hydrogels Usable for Infected Wound Healing

The aim of this study was to develop new hydrogels for infected wound treatment. The main components of hydrogels were two proteins, one fibrous (type I collagen in the form of gel) and one globular (albumin) in different ratios (10, 20 and 30%), and gentamicin was selected as an antibiotic drug model. The properties of the obtained hydrogels were estimated by rheological measurements and the corresponding lyophilized forms by water up-take capacity. The results showed that the promising hydrogels which can provide good absorbance and antimicrobial properties at the same time are the ones with maximum 20% albumin and 0.2% gentamicin and the in vitro tests are further recommended.