HYSTO- AND CYTOMORPHOLOGICAL AGE-RELATED CHANGES IN LIVERS OF EXPERIMENTAL RODENTS, WHO WERE UNDER SYSTEMIC HYPERGRAVITATION INFLUENCE

The article deals with the liver structural changes of experimental rodents of juvenile age, who were under 10- or 30-times hypergravitation influence. These changes mostly have reversible character and are accompanied by adaptive-compensative mechanism activization. They are directed to reduce negative influence of exogenic factors. Both structural-functional changes and adaptive reaction intensivety dominate in the rodent subgroup, which got more influence. Obtained gysto- and cytomorphological data prove positive adaptive response establishment on cellular level. First of all this positive adaptive response is characterized by cell quantity increasing of different mitosis stages. Most obvious histopathological changes were found in the mature rodent subgroup, which are characterized by cytomorphological traits of the vacuolar degeneration and non-adequate adaptive response realization. However, more obvious negative influence of the overload was pointed in the longer term experiment (30-times hypergravitation influence).