Histopathological features and immunoflorescence patterns in skin lesions

The diagnosis of vesiculo-bullous lesions and many other diseases is fundamentally based on the microscopic study of cells and tissues. This diagnostic method remains the standard, by which all other diagnostic tests are measured. Nevertheless, the era of the pathologist relying entirely on the examination of tissue sections stained by histochemical methods is gradually being replaced by a time when advanced immunologic and molecular techniques (i.e. analysis of DNA, RNA or protein structure and function) augment the process by which complicated diseases are classified.