Circulating adiponectin regulates serum C - reactive protein and Interleukine-6 in obesity

Impaired adiposity-secreted adipocytokines is known to be associated with obesity and related diseases. The aim of this study was to assess the association between antiinflammatory cytokine adiponectin with C-reactive protein and interleukine-6 as two important pro-inflammatory cytokine in thirty nine sedentary healthy obese men aged 35 – 45 years. For this purpose, venous blood samples were collected from each subject after overnight fast in order to measuring serum adiponectin, CRP and Il-6. All anthropometrical variables were also measured. Pearson correlations were used to establish the relationship between adiponectin concentration with CRP and Il-6 in studied subjects. A significant negative correlation was observed between adiponectin (p = 0.022, r = 0.37) and Il-6 (p = 0.009, r = 0.41). Our data suggests that high adiponectin is associated low pro-inflammatory cytokine. We can say Serum adiponectin may affects circulating CRP an Il-6 as two inflammatory mediators and markers of increased cardiovascular risk.