CORRELATION OF VARIOUS BIOCHEMICAL PARAMETERS WITH THE SEVERITY OF PREGNANCY INDUCED HYPERTENSION

Abstract : INTRODUCTION Pre-eclampsia (PE) is the most common and deadly complication which occurs during pregnancy, which is fatal to both the mother and the fetus. The study of various biochemical parameters is gaining ground in the pathophysiology of hypertension and to assess the severity of PE. AIMS AND OBJECTIVES To determine the correlation of various biochemical parameters, that is serum lipid profile, electrolytes, uric acid, hsCRP in the pathogenesis and severity of PE. MATERIALS AND METHODS Includes 100 cases which is divided into two groups GROUP 1includes 50 women in the third trimester of pregnancy with PE at the time of admission, which is subdivided in to GROUP 1A - 30 women in the third trimester of pregnancy with mild PE at the time of admission. GROUP 1B - 20 women in the third trimester of pregnancy with severe PE were included. GROUP 2 - 50 healthy normotensive women in the third trimester of pregnancy were included. 5ml of fasting blood sample was collected and estimation of hsCRP was done by Immunoturbidimetric assay, uric acid and lipid profile by Enzymatic method, calcium by O-CPC method, magnesium by Calmagite method, sodium and potassium by ISE. RESULTS In our study it was found that serum hsCRP, uric acid, triglycerides, total cholesterol and LDL-C were all found to have significant positive correlation, while serum calcium, magnesium and HDL-C were found to be negatively correlated with the severity of PE. CONCLUSION We therefore conclude that all these biochemical parameters contribute to the pathogenesis of PE and can be used to predict the severity of PE in addition to blood pressure and proteinuria