Anti-Diabatic Activity of Herbal Extract Mixture

Indian system of medicine, Siddha has mentioned numerous plants for the treatment of diabetes. In folk medicine they are effective either single (or) combinational therapy. Based on ethnopharmacological sources, the potent hypoglycemic herbs of Indian origin Solanum xanthocarpum and Terminalia belerica were selected for the present work. The plants were extracted with solvents of increasing polarity. Further all the extracts were screened for antioxidant property by in vitro nitric oxide assay to determine its potential to scavenging the free radical. From that aqueous extract of the both plants was selected and prepared in different combination ratio from 10:90, 20:80 30:70, 40:60, 50:50,60:40,70:30,80:20,90:10 (Terminalia belerica: Solanum xanthocarpum). The safety profile of the herbal extract mixture was studied by acute toxicity. The selected bio active herbal extract was subjected into antidiabetic activity by STZ induced medthod. Antidiabetic activity of herbal extract mixture showed that blood glucose level was significantly decreased in diabetic rats at both the tested dose levels. Herbal extract mixture significantly lower the biochemical parameter SGOT, SGPT, Total cholesterol and Serum triglyceride as compared to diabetic rat. Extract mixture has shown significant reduction of SOD and GPX in diabetic rats.