ETIOLOGY AND PATHOGENESIS OF ATOPIC DERMATITIS

This article considers the actual problem of the etiology and pathogenesis of hereditary dermatosis, which is atopic dermatitis. The defects in the barrier function of the epidermis, innate immunity and defects in immune regulation in atopic dermatitis are described in detail. The article is also focused on the participation of protease-inhibitor receptors PAR-1, PAR-2, PAR-3, PAR-4 in the mechanism of dermatosis development, mutations in the gene filaggrin and in utero sensitization of the fetus by food allergens. The characteristic of specific and nonspecific trigger factors is given.