ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login

Intestinal IL-17 Expression in Canine Inflammatory Bowel Disease

Journal: International Journal of Veterinary Health Science & Research (IJVHSR) (Vol.05, No. 03)

Publication Date:

Authors : ; ; ; ; ; ;

Page : 171-175

Keywords : CD: Crohn’s Disease; IBD: Inflammatory Bower Disease; IHC: Immunohistochemistry; UC: Ulcerative Colitis;

Source : Downloadexternal Find it from : Google Scholarexternal

Abstract

IL-17 plays important roles in human inflammatory bowel disease (IBD). However, little is known about the possible relation of IL-17 in canine IBD. For comparative medicine and canine disease, it is useful to demonstrate the role of IL-17 in canine IBD. In this study, 7 cases of the dog with IBD typed of lymphocytic-plasmacytic enteritis without Intestinal lymphoma were examined immunohistochemically for possible relation with IL-17. Here, we found that IL-17 is expressed in intestinal mucosa of the dog with IBD. Among 7 cases, there are strong expressions of IL-17 in cases 2, moderate expression of it in cases 2, weak expression of it in cases 2, and very low expression of it in case 1. The score of IL-17 expression is not correlated with sex, age, and the breed. Using biopsy specimen, our results revealed the immunopathological relevance of IL-17 in the dog with IBD.

Last modified: 2017-05-26 19:28:50