Intestinal IL-17 Expression in Canine Inflammatory Bowel Disease
Journal: International Journal of Veterinary Health Science & Research (IJVHSR) (Vol.05, No. 03)Publication Date: 2017-04-04
Authors : Kinjo T; Azuma YT; Nishiyama K; Fujimoto Y; Miki M; Kuramoto N;
Page : 171-175
Keywords : CD: Crohn’s Disease; IBD: Inflammatory Bower Disease; IHC: Immunohistochemistry; UC: Ulcerative Colitis;
Abstract
IL-17 plays important roles in human inflammatory bowel disease (IBD). However, little is known about the possible relation of IL-17 in canine IBD. For comparative medicine and canine disease, it is useful to demonstrate the role of IL-17 in canine IBD. In this study, 7 cases of the dog with IBD typed of lymphocytic-plasmacytic enteritis without Intestinal lymphoma were examined immunohistochemically for possible relation with IL-17. Here, we found that IL-17 is expressed in intestinal mucosa of the dog with IBD. Among 7 cases, there are strong expressions of IL-17 in cases 2, moderate expression of it in cases 2, weak expression of it in cases 2, and very low expression of it in case 1. The score of IL-17 expression is not correlated with sex, age, and the breed. Using biopsy specimen, our results revealed the immunopathological relevance of IL-17 in the dog with IBD.
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