Magnesium Deficiency Results in Oxidation and Fragmentation of DNA, Down Regulation of Telomerase Activity, and Ceramide Release in Cardiovascular Tissues and Cells: Potential Relationship to Atherogenesis, Cardiovascular Diseases and Aging
Journal: International Journal of Diabetology & Vascular Disease Research (IJDVR) (Vol.04, No. 02)Publication Date: 2016-02-22
Authors : Altura BM; Shah NC; Gatha J. Shah; Pérez-Abela JL; Altura BT;
Page : 1-5
Keywords : Ceramide; Nuclear Factor kB; Proto-Oncogenes; Sphingolipids; Cytokines; p53.;
Abstract
Aging is clearly agreed to be critical in the etiology of metabolic decline in most human subjects as they near their 65th birthday. A great many human subjects at 65 years of age demonstrate clear signs of metabolic and physiological decline, atherosclerosis in most major arteries, high blood pressure, high serum cholesterol levels, diverse cardiovascular diseases, and often type 2 diabetes mellitus, which contribute in major ways to congestive heart failure by their 75th-85th years. It must be pointed out, here, that all of these aberrations have been shown (or to be associated with) both experimentally and clinically, with the presence of magnesium deficiency (MgD)
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