Study of Insulin Secretory Response after Oral Glucose Load in Obese Subjects

Background: Insulin resistance leads to impaired glucose tolerance, dyslipidemia, and other adverse cardiovascular effects. Increased insulin resistance will lead to hyperinsulinemia which is a characteristic feature of obesity, hypertension and type 2 Diabetes mellitus. Aims: The present study was designed to investigate insulin secretory response and glucose abnormalities after oral glucose load in obese subjects. Material and Method: The present study was carried out on 25 healthy controls and 25 obese subjects of either sex and of varying age groups attending the Out Patient Department of Medicine, Dr. S.N. Medical College and Associated group of hospitals, Jodhpur. Results: The results obtained in this study showed that the results of standard OGTT and corresponding insulin response during fasting, after 1 hour & 2 hour were significantly higher in patients compared with control subjects. Conclusion: The present study indicates an increased insulin secretory response in obese subjects, which is due to higher insulin resistance.