Drug-eluting Stents in Premature Coronary Disease in Young People with Homozygous Familial Hypercholesterolemia and Prior Liver Transplant. A Report of Two Cases

Lipoprotein metabolism disorders, as well as high fat diets, obesity and physical inactivity have given rise to an atherosclerotic disease epidemic worldwide. The interaction of these adverse environmental factors with genetic and acquired lipoprotein disorders predispose to an increasingly earlier development of atherosclerosis. In the United States, mortality due to coronary artery disease (CD) in middle aged people has decreased by 31% during the last decade. However, atherosclerotic cardiovascular disease continues to be the most frequent cause of death, both in men and women. The general mortality rate due to cardiovascular diseases is 235.5 per 100,000 population and CD only caused 1 out of 6 deaths in the United States in 2010