New Analytical Methods for Titrimetric and Spectrophotometric Analysis of Salicylic Acid Bulk Drug Sample

Titrimetric analysis of salicylic acid by Indian Pharmacopoeial method employ the use of ethanol. Organic solvents such as ethanol, chloroform, benzene etc. are costly and possess toxicity and environmental hazard. In order to overcome above drawbacks the concept of mixed solvency could be employed. The aim of present study was to avoid the use of organic solvents and enhance the solubility of salicylic acid in aqueous medium contains solubilizers such as sodium citrate (5% w/v), glycerin (5% w/v), PEG 400 (5% w/v), urea (5% w/v), PEG 300 (10% w/v) and PEG 4000 (10% w/v) correspondingly. A blend of these solubilizing agents used to improve the solubility of salicylic acid by many folds. From the statistical data it was proved that the proposed methods are accurate, precise and reproducible. The concept thus can be a boon in pharmaceutical field as well as a way towards the green chemistry.