Effect of Titanium Trichloride on Protein Contents of Foetal Organs During Various Period of Gestation in Rats

Protein contents have been studied in the of foetal organs during various period of gestation in rats liver, kidney and placenta of pups dilevered from mother exposed to titanium trichloride. A significant decrease in protein contents was observed during organogenesis liver and placenta of pups at 0.36 ml/kg of dose of titanium trichloride administrated from 6th to 14th day of gestation. However no significant changes were observed during foetal development (15th to 20th day of gestation). The wet weight of foetal liver and Placenta was significantly decreased during treatment from 6th to 14th and 15th to 20th day of gestation at 0.36 ml/kg of daily dose and 9 th days at 0.72 ml/kg of single dose. It appears that titanium may inhibit certain key enzyme necessary for protein synthesis and thus decreased the protein contents in foetal liver and placenta without any effect on kidney.