A Rare Case of Small Cell Neuroendocrine Carcinoma of the Nasal Cavity and Paranasal Sinuses

Introduction: Neuroendocrine neoplasms are defined as epithelial neoplasms with predominant neuroendocrine differentiation. They are most commonly found in the gastrointestinal tract and respiratory system. Nasal cavity and paranasal sinuses are a rare site for neuroendocrine carcinoma; it's reported as a recurrent entity and locally destructive tumor. Very few cases of paranasal sinus neuroendocrine carcinoma have been reported till date. We report one such case and discuss the specificities of this location. The paper represents recent treatment trends that may result in improved loco regional control and survival Case report: We report the case of 42-year-old women without known pathological history, who presented with bilateral nasal obstruction with purulent rhinorrhea since 2 months. Diagnosis was made on the basis of immunohistochemical study of biopsy samples. Treatment, comprising chemotherapy followed by radiotherapy, achieved total remission at 9 months follow-up. Discussion/Conclusion: Neuroendocrine neoplasms are rare. Diagnosis is based on immunophenotypic and molecular characteristics. It is an aggressive neoplasm, requiring multidisciplinary management.