Antibacterial Properties of Some Macromycetes

Background. The constant emergence of pathogen forms and their new species multi-resistant to existing drugs, and the frequent occurrence of side effects of these drugs cause need to find new antibiotic compounds, especially anti­biotics of natural origin (from plants, fungi, mosses). Fungi are promising object of research because of pro­duction of various biologically active substances. Objective. The aim of the paper is to analyze the results of research of antibacterial properties of various macromycetes representatives and determine prospects of their practical application. Methods. The analysis and generalisation of information about objects and methods of macromycetes antibacterial activity research. Results. Much attention is paid to Basidiomycetes among macromycetes, especially species of the genus Agaricus, Ganoderma, Lentinus, Phellinus, Pleurotus, Polyporus, Trametes. In practice macromycetes are used both as fruiting bodies, biomass and culture liquid and as isolated antibiotic substances. Therefore, edible species of fungi are preferred (Agaricus sp., Pleurotus sp. and Lentinus sp.). Conclusions. Considering the diversification of investigations dedicated to the search for antibacterial properties of fungi, obtained data on antibiotic activity are quite hard to generalize. Studying of antibacterial activity, action mechanisms is especially important and promising research direction of antibacterial compounds found in macromycetes for further implementation of antibiotics and/or components based on culture liquid, mycelium and fruiting bodies of fungi.