PLANIMETRIC ANALYSES OF THE BURN AREAS AFTER CHITOSAN MEMBRANES APPLICATIONJournal: Journal of Clinical and Experimental Medical Research(JC&EMR) (Vol.1, No. 4)
Publication Date: 2013-12-15
Authors : Kornienko V. V.;
Page : 390-397
Keywords : burns; treatment; medicines; chitosan; planimetria;
The article is devoted to evaluate dynamics of planimetric indexes of burns. I took rats of different age and applied innovative chitosan membranes on the burns. I modeled IIIb burns on the rats from both experimental and control groups; I used chitosan-based coatings for topical treatment. Planimetric analyses of the affected areas were performed by the “SEO Image lab 2.0” program (Sumy, Ukraine) considering the total affected area(sm2); the relative areas of dead tissue, granulation tissue and epithelization (%). I measured them on 1st, 3rd, 7th, 14th and 21st days after the burn modelling. These days show key phases of skin healing. I determined the rate of burn healing according to certain criteria: average rate of affected area reduction (sm2) per day; reduction in burn area (%) per day. Natural chitosan coatings prevented from repeated infections protecting the burn areas from exogenous factors. Besides, it was applied easily on the affected areas to protect newly formed epithelium. Healing process speeded up during the inflammatory phase as both burn cleaning and granulation tissue formation enhanced. Moreover, gripping of the burn edges occurred during the proliferation and remodeling phases. Due to these results I may claim that period of healing process with rate of epithelization has decreased by 1.5 day.
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