EFFECTIVENESS CRITERIA OF THE TREATMENT WITH METFORMIN FOR PATIENTS WITH POLYCYS TIC OVARY SYNDROME AND OBESITY

The study involved 35 patients with polycystic ovary syndrome and obesity. According to the basal secretion of аnti-Müllerian hormone, all patients were divided into two groups: the first group consisted of 20 women with index >10.3 ng / ml (14.1 ± 0.5 ng / ml) and the second ? 15 women with index < 10.3 ng / ml (9.2 ± 0.2 ng / ml). I noticed similar changes in both groups after six month of therapy with metformin: weight loss, decrease of insulin, luteinizing hormone, testosterone and increase sex hormone-binding globulin, which was accompanied by reduction of free androgen index. Besides, the number of antral follicles and volume of ovarian reduced, menstrual cycle normalized. Perhaps, pregnancy occurred only among the representatives from the second group. We assumed that the basal secretion of аnti-Müllerian hormone could be a predictor of clinical effectiveness of treatment with metformin.