THE PROTOCOL OF PATHOMORPHOLOGICAL INVESTIGATION OF THE PERIPHERAL NERVE HAEMOCIRCULATORY BLOOD STREAM

Peripheral neuropathy is a clinical syndrome that develops as a result of various aetiological factors impacting peripheral nerves. It is distinguished by heterogeneous pathogenetic mechanisms. Polioneuropathies occupy the second place in the structure of diseases of the peripheral nerve system after vertebraginic pathology, but greatly exceed it in the complicated clinical manifestations and crippling consequences. Important role is played by the vessel factors of neuropathy development, which are connected with the involvement of vasa nervorum and combine a big group of diseases. To detect the pathological changes in the microcirculatory blood stream of peripheral nerves advanced pathohistological research of its components on various levels is needed; this research is carried out by pathologists with the use of the whole complex of techniques aimed at the elective detection of various elements of vessel wall. The issue of protocol development enabling the complex multi-factor analysis of great amounts of data is therefore in question. The objective of our research is the development of the systematic list of pathohistological changes in the microcirculatory blood stream of the peripheral nerve. The research protocol for the description of pathohistological changes of some components of the microcirculatory stream of the peripheral nerve was developed based on referenced data and our own observation experience. The systematic list of pathohistological changes was verified in the examination of 220 n. tibialis of diabetes patients and in the control group. The use of the suggested research protocol for the description of pathomorphological changes in vessels will enable objective diagnosis and correct interpretation of the obtained data. The prospects of our research lie in the development of the computer-based morphometric analysis of the haemocirculatory blood stream of peripheral nerves.